SYNTHESIS OF MYCOPHENOLIC ACID β-D-GLUCURONIDE AND ITS ANTITUMOR ACTIVITY
نویسندگان
چکیده
منابع مشابه
Antitumor activity of mycophenolic acid.
n our laboratory in 4CS mice. (3) Mouse ascites hepatoma, MH134, was converted into ascitic form by Sato et al.*\ from a C3H/HeN mouse hapatoma induced after treatment with carbon tetrachloride by Andervont et al.5) It has been maintained in C3H/He mice with distinct strain specificity in tumor take in our laboratory. (4) Mouse ascites sarcoma, SR-C3H/He Th62, was originally induced with Schmid...
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One hundred and eight derivatives of mycophenolic acid (MA) have been prepared by modifications at the phenolic hydroxyl and/or carboxyl sites. None of these compounds was as effective as MA in suppressing cell growth of L-518Y cell in vitro, whereas several compounds with changes at both the hydroxyl and carboxyl groups were more effective than MA against Ehrlich solid carcinoma and L-1210 leu...
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Inosine 5'-monophosphate dehydrogenase (IMP-DH) activities were measured in human lymphocytes (exhibiting type I IMP-DH activity) and human lymphoblasts (exhibiting type II IMP-DH activity) in the presence of various amounts of mycophenolic acid (MPA) (0-20 mumol/L) and MPA glucuronide (MPAG) (0-200 mumol/L). Moreover, the influences of human serum albumin (HSA) and human plasma on the MPA- and...
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The interaction between mycophenolate (MPA) and quinolone antibiotics such as ciprofloxacin is considered to reduce the enterohepatic recycling of MPA, which is biotransformed in the intestine from MPA glucuronide (MPAG) conjugate excreted via the biliary system; however, the molecular mechanism underlying this biotransformation of MPA is still unclear. In this study, an in vitro system was est...
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2010 platform (Roche Diagnostics). Ionized calcium and 25-hydroxyvita-min D (Nichols Advantage) were also measured in all samples. Results for the healthy individuals are presented in Fig. 1. The bio-intact PTH values measured by the IRMA and chemiluminescence immunoas-say were, on average, 50% and 30% lower, respectively, than the PTH measured by the Elecsys. Regression analysis demonstrated s...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1970
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.23.408